Article
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.
Nature communications - 28 Jan 2021
Lin Wei-Yu, Fordham Sarah E, Sunter Nicola, Elstob Claire, Rahman Thahira, Willmore Elaine, Shepherd Colin, Strathdee Gordon, Mainou-Fowler Tryfonia, Piddock Rachel, Mearns Hannah, Barrow Timothy, Houlston Richard S, Marr Helen, Wallis Jonathan, Summerfield Geoffrey, Marshall Scott, Pettitt Andrew, Pepper Christopher, Fegan Christopher, Forconi Francesco, Dyer Martin J S, Jayne Sandrine, Sellors April, Schuh Anna, Robbe Pauline, Oscier David, Bailey James, Rais Syed, Bentley Alison, Cawkwell Lynn, Evans Paul, Hillmen Peter, Pratt Guy, Allsup David J, Allan James M
Abstract excerpt
Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic locations associated with time from diagnosis to treatment, including 10q26.13 (rs736456, hazard...
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