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Pathogen Adaptation of HLA Alleles and Its Correlation with Autoimmune Diseases in the Han Chinese.

Genomics, proteomics & bioinformatics - 30 May 2025

Liu Shuai, Li Yanyan, Song Tingrui, Zhang Jingjing, Zhang Peng, Luo Huaxia, Zhang Sijia, Niu Yiwei, Xu Tao, He Shunmin

Abstract excerpt

Human leukocyte antigen (HLA) genes play a crucial role in the adaptation of human populations to the dynamic pathogenic environment. Despite their significance, investigating the pathogen-driven evolution of HLAs and its implications for autoimmune diseases presents considerable challenges. Here, we genotyped over 20 HLA genes at 3-field resolution in 8278 individuals from diverse ethnic backgrounds, including...

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Identifiers

PMID: 40300101
DOI: 10.1093/gpbjnl/qzaf038
PMCID: PMC12368854

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