Article

The Pathogen Adaptation of HLA Alleles and the Correlation with Autoimmune Diseases based on the HLA Diversity Resource in the Han Chinese

2024-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Human leukocyte antigen (HLA) genes play a crucial role in the adaptation of human populations to the dynamic pathogenic environment. Despite their significance, investigating the pathogen-driven evolution of HLAs and the implications for autoimmune diseases presents considerable challenges. Here, we genotyped over twenty HLA genes at 3-field resolution in 8278 individuals from diverse ethnic bac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9f62975-b645-55cb-b67a-136d83ece4c9
DOI: 10.1101/2024.11.19.24317546

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Pathogen Adaptation of HLA Alleles and the Correlation with Autoimmune Diseases based on the HLA Diversity Resource in the Han ChineseDOI 10.1101/2024.11.19.24317546Read

Pathogen Adaptation of HLA Alleles and Its Correlation with Autoimmune Diseases in the Han Chinese.Semantic proximity Read

A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations.Semantic proximity Read

Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections.Semantic proximity Read

Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease.Semantic proximity Read

PGG.MHC: toward understanding the diversity of major histocompatibility complexes in human populations.Semantic proximity Read

Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2.Semantic proximity Read

Distribution of HLA allele frequencies in 82 Chinese individuals with coronavirus disease-2019 (COVID-19).Semantic proximity Read

Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases.Semantic proximity Read

A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.Semantic proximity Read

[Study on the association between genetic variation of gag gene and HLA restricted CTL response in HIV-1 B' infected Chinese people].Semantic proximity Read

Human and pathogen genotype-by-genotype interactions in the light of coevolution theory.Semantic proximity Read

Natural LILRB1 D1-D2 variants show frequency differences in populations and bind to HLA class I with various avidities.Semantic proximity Read