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A Dual-Capture and Dual-Output 3D DNA Walker System Integrated with Ligases Enables Ultrasensitive Detection of Single-Nucleotide Polymorphisms.

Analytical chemistry - 6 May 2025

Zhang Yunshan, Tan Qianglong, Yang Fang, Huang Tuo, Yu Siyu, Ye Jing, Zeng Jianxian, Feng Xianzhong, Zhang Diming

Abstract excerpt

DNA walkers, as structurally and functionally programmable signal amplification tools, exhibit great potential for application in the field of biosensing. Traditional DNA walkers often rely on enzymes for operation, posing compatibility challenges, while the handful of existing enzyme-free DNA walkers demonstrate limited performance. To address this, we innovatively developed an efficient enzyme-free 3D DNA...

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PMID: 40281399
DOI: 10.1021/acs.analchem.5c00028

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