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Conformationally Regulated CRISPR/Cas12a Activation Enabled by a Programmable DNA Dumbbell for Electrochemical SNP Genotyping.

Analytical chemistry - 14 Apr 2026

Ye Jing, Tang Xiang, Chen Yuhan, Guo Rui, Zhang Wei, Wang Meng, Yang Ximiao, Deng Weiping, Zhang Yunshan, Feng Xianzhong, Hu Ning, Zhang Diming

Abstract excerpt

Single-nucleotide polymorphism (SNP) genotyping is crucial for genetic research and precision medicine, yet reliable discrimination of single-base variants in complex genomic backgrounds remains analytically challenging. Although CRISPR/Cas12a-based biosensing offers high sequence specificity, its intrinsic mismatch tolerance often leads to nonspecific activation by wild-type sequences, thereby compromising SNP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41911023
DOI: 10.1021/acs.analchem.6c00333

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