Article
Entropy-Driven Catalytic G-Quadruple Cycle Amplification Integrated with Ligases for Label-Free Detection of Single Nucleotide Polymorphisms.
Analytical chemistry - 17 Sept 2024
Zhang Yunshan, Yang Fang, Huang Tuo, Xu Shijie, Ye Jing, Weng Lin, Hu Ye, Huang Haowen, Li Shuang, Zhang Diming
Abstract excerpt
G-Quadruplex/thioflavin (G4/THT) has become a very promising label-free fluorescent luminescent element for nucleic acid detection due to its good programmability and compatibility. However, the weak fluorescence efficiency of single-molecule G4/THT limits its potential applications. Here, we developed an entropy-driven catalytic (EDC) G4 (EDC-G4) cycle amplification technology as a universal label-free signal...
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