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Advanced Ligase Chain Reaction Strategy to Generate a Circular DNA Walker for Electrochemiluminescent Detection of Single Nucleotide Polymorphism.

Analytical chemistry - 31 Dec 2024

Yan Lu, Tao Xiu-Li, Chen Qiao-Lin, Li Wen, Chai Ya-Qin, Yuan Ruo, Lei Yan-Mei, Zhuo Ying

Abstract excerpt

Single nucleotide polymorphism (SNP) primarily refers to DNA sequence polymorphism caused by variations in a single nucleotide, which is closely associated with many diseases such as genetic disorders and tumors. However, trace DNA mutants typically exist in a large pool of wild-type DNA, making it challenging to establish accurate and sensitive approaches for SNP detection. Herein, we developed an advanced...

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Biosensing Techniques
DNA, Circular
Electrochemical Techniques
Limit of Detection
Luminescent Measurements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 39692131
DOI: 10.1021/acs.analchem.4c05189

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