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Entropy-Driven Circuit Integrated with Ligases to Regulate DNA-AuNP Network Disintegration for Colorimetric Detection of Single Nucleotide Polymorphisms.

Analytical chemistry - 4 Mar 2025

Zhang Yunshan, Huang Tuo, Yang Fang, Tan Qianglong, Ye Jing, Feng Xianzhong, Zhang Diming

Abstract excerpt

In recent years, entropy-driven circuit (EDC) dynamic DNA networks have garnered significant attention in nucleic acid detection owing to their simplicity, efficiency, and flexible design. Nevertheless, conventional EDC reactions face a constraint in achieving optimal signal amplification due to a solitary and feeble driving force. To overcome this limitation, we innovatively devised a gold nanoparticle (AuNP)...

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PMID: 39973570
DOI: 10.1021/acs.analchem.4c06146

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