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RCA-Supported Multipedal DNA Walker Integrated with TSDR for Simultaneous Detection of Single Nucleotide Polymorphisms in Circulating Tumor DNA.

Analytical chemistry - 25 Mar 2025

Li Wei, Li Jiayue, Lin Minzhao, Liu Kai, Liu Xiaoting, Zhou Yi, Wang Rui

Abstract excerpt

Peripheral blood circulating tumor DNA (ctDNA) is a crucial liquid biopsy biomarker that correlates overall systemic tumor burden with malignant progression. However, identifying multiple single nucleotide polymorphisms (SNPs) in ctDNA presents significant challenges. In this study, we developed a rolling circle amplification (RCA)-supported multipedal DNA walker integrated with toehold-mediated strand...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40072018
DOI: 10.1021/acs.analchem.5c00557

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