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Article

The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15.

The EMBO journal - 1 Jun 2025

Dudziak Alexander, Pleuger Richard, Schmidt Jasmin, Hamm Frederik, Tendulkar Sharvari, Jänen Karolin, Vetter Ingrid R, Singh Sylvia, Fischböck Josef, Herzog Franz, Westermann Stefan

Abstract excerpt

Kinetochores link chromosomes to dynamic microtubules of the mitotic spindle. To ensure equal chromosome segregation, sister chromatids must achieve biorientation. The conserved kinase Aurora B phosphorylates outer kinetochore proteins on attachments lacking tension, allowing the re-establishment of new connections until biorientation is achieved. Aurora B localizes to the centromere as part of the chromosomal...

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Identifiers

PMID: 40281358
DOI: 10.1038/s44318-025-00437-w
PMCID: PMC12170873

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The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15.PMID 40281358Read ↗

Bir1 is required for the tension checkpoint.Semantic proximity Read ↗

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.Semantic proximity Read ↗

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.Semantic proximity Read ↗

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.Semantic proximity Read ↗

Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.Semantic proximity Read ↗

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.Semantic proximity Read ↗

Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex.Semantic proximity Read ↗

Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint.Semantic proximity Read ↗

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.Semantic proximity Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase.Semantic proximity Read ↗

The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly.Semantic proximity Read ↗

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