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Article

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.

The Journal of cell biology - 2 Dec 2019

Roy Babhrubahan, Verma Vikash, Sim Janice, Fontan Adrienne, Joglekar Ajit P

Abstract excerpt

Accurate chromosome segregation during cell division requires the spindle assembly checkpoint (SAC), which detects unattached kinetochores, and an error correction mechanism that destabilizes incorrect kinetochore-microtubule attachments. While the SAC and error correction are both regulated by protein phosphatase 1 (PP1), which silences the SAC and stabilizes kinetochore-microtubule attachments, how these...

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Identifiers

PMID: 31649151
DOI: 10.1083/jcb.201810172
PMCID: PMC6891095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.PMID 31649151Read ↗

KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint.Semantic proximity Read ↗

Captivating capture: how microtubules attach to kinetochores.Semantic proximity Read ↗

The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15.Semantic proximity Read ↗

SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation.Semantic proximity Read ↗

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.Semantic proximity Read ↗

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.Semantic proximity Read ↗

Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.Semantic proximity Read ↗

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.Semantic proximity Read ↗

Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p.Semantic proximity Read ↗

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.Semantic proximity Read ↗

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.Semantic proximity Read ↗

The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly.Semantic proximity Read ↗

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