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Article

An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase.

Developmental cell - 1 Nov 2003

Pinsky Benjamin A, Tatsutani Sean Y, Collins Kimberly A, Biggins Sue

Abstract excerpt

Chromosome segregation depends on kinetochore biorientation so that sister kinetochores attach to microtubules from opposite poles and come under tension. The budding yeast Ipl1/Aurora protein kinase allows the absence of tension to activate the spindle checkpoint. We found that checkpoint activation in the mtw1-1 kinetochore mutant requires Ipl1p, suggesting that Mtw1p promotes tension. We isolated mtw1-1 dosage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14602074
DOI: 10.1016/s1534-5807(03)00322-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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