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Article

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.

Nature cell biology - 1 Jan 2006

Pinsky Benjamin A, Kung Charles, Shokat Kevan M, Biggins Sue

Abstract excerpt

The spindle checkpoint ensures accurate chromosome segregation by delaying cell-cycle progression until all sister kinetochores capture microtubules from opposite poles and come under tension (for reviews, see refs 1, 2). Although the checkpoint is activated by either the lack of kinetochore-microtubule attachments or defects in the tension exerted by microtubule-generated forces, it is not clear whether these...

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PMID: 16327780
DOI: 10.1038/ncb1341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.PMID 16327780Read ↗

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.Semantic proximity Read ↗

The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.Semantic proximity Read ↗

Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint.Semantic proximity Read ↗

Laterally attached kinetochores recruit the checkpoint protein Bub1, but satisfy the spindle checkpoint.Semantic proximity Read ↗

Bir1 is required for the tension checkpoint.Semantic proximity Read ↗

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.Semantic proximity Read ↗

An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase.Semantic proximity Read ↗

Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p.Semantic proximity Read ↗

Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.Semantic proximity Read ↗

The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15.Semantic proximity Read ↗

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.Semantic proximity Read ↗

Kinetochore biorientation in Saccharomyces cerevisiae requires a tightly folded conformation of the Ndc80 complex.Semantic proximity Read ↗

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