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Article

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.

Cell - 8 Feb 2002

Tanaka Tomoyuki U, Rachidi Najma, Janke Carsten, Pereira Gislene, Galova Marta, Schiebel Elmar, Stark Michael J R, Nasmyth Kim

Abstract excerpt

How sister kinetochores attach to microtubules from opposite spindle poles during mitosis (bi-orientation) remains poorly understood. In yeast, the ortholog of the Aurora B-INCENP protein kinase complex (Ipl1-Sli15) may have a role in this crucial process, because it is necessary to prevent attachment of sister kinetochores to microtubules from the same spindle pole. We investigated IPL1 function in cells that...

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Share to Aurora Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11853667
DOI: 10.1016/s0092-8674(02)00633-5

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.PMID 11853667Read ↗

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.Semantic proximity Read ↗

Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.Semantic proximity Read ↗

The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15.Semantic proximity Read ↗

An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase.Semantic proximity Read ↗

<i>Drosophila</i> kinesin-8 stabilises the kinetochore-microtubule interactionSemantic proximity Read ↗

Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle.Semantic proximity Read ↗

Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast.Semantic proximity Read ↗

The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly.Semantic proximity Read ↗

Interphase microtubule bundles use global cell shape to guide spindle alignment in fission yeast.Semantic proximity Read ↗

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.Semantic proximity Read ↗

Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.Semantic proximity Read ↗

Slk19 clusters kinetochores and facilitates chromosome bipolar attachment.Semantic proximity Read ↗

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