Article
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.
American journal of physiology. Heart and circulatory physiology - 1 Aug 2006
Gaffin Robert D, Gokulan Kuppan, Sacchettini James C, Hewett Timothy E, Klevitsky Raisa, Robbins Jeffrey, Sarin Vandana, Zawieja David C, Meininger Gerald A, Muthuchamy Mariappan
Abstract excerpt
The ends of striated muscle tropomyosin (TM) are integral for thin filament cooperativity, determining the cooperative unit size and regulating the affinity of TM for actin. We hypothesized that altering the alpha-TM carboxy terminal overlap end to the beta-TM counterpart would affect the amino-terminal association, which would alter the end-to-end interactions of TM molecules in the thin filament regulatory...
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