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Article

Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD.

Journal of the American Society of Nephrology : JASN - 1 Apr 2018

Komada Takanori, Chung Hyunjae, Lau Arthur, Platnich Jaye M, Beck Paul L, Benediktsson Hallgrimur, Duff Henry J, Jenne Craig N, Muruve Daniel A

Abstract excerpt

Nonmicrobial inflammation contributes to CKD progression and fibrosis. Absent in melanoma 2 (AIM2) is an inflammasome-forming receptor for double-stranded DNA. AIM2 is expressed in the kidney and activated mainly by macrophages. We investigated the potential pathogenic role of the AIM2 inflammasome in kidney disease. In kidneys from patients with diabetic or nondiabetic CKD, immunofluorescence showed AIM2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29439156
DOI: 10.1681/ASN.2017080863
PMCID: PMC5875955

Genes

AIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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