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DNA damage-induced AIM2 pyroptosis in high glucose-induced proximal tubular epithelial cell

26 Nov 2024

Abstract excerpt

Pyroptosis is one of the ways to cause proximal tubular epithelial cell death in diabetic nephropathy (DN), but the exact mechanism remains unclear. Absent in melanoma 2 (AIM2), a sensor for double-stranded DNA, creates an inflammasome that triggers the cleavage of gasdermin D (GSDMD), leading to a type of inflammatory cell death called pyroptosis. This study investigated the role of AIM2 in pyroptosis within...

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PMID: 39659523
DOI: 10.3389/fcell.2024.1457369

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