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The Calcium-Calpain-ALIX Axis is the Major Link Between Gasdermin-D Membrane Pores and Terminal Membrane Damage in Pyroptosis

2026-06-29

Abstract excerpt

<title>Abstract</title> <p> Pyroptosis is an inflammatory form of regulated cell death driven by gasdermin-mediated membrane pore formation. Although gasdermin D (GSDMD) pores are widely regarded as the executioners of pyroptosis, recent studies demonstrate that pore formation is not necessarily lethal because cells can actively repair membrane damage through the Endosomal Sorting Complex Required for Transport...

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Literature Corpus work
7ca014de-bb03-51db-8ea3-8bd90c07caa1
DOI
10.21203/rs.3.rs-10100112/v1
Open publication

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The Calcium-Calpain-ALIX Axis is the Major Link Between Gasdermin-D Membrane Pores and Terminal Membrane Damage in PyroptosisDOI 10.21203/rs.3.rs-10100112/v1
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