Article

Rapid Podocyte ablation Causes Acute Renal Tubule Cell Necrosis and Interstitial Fibrosis

2026-03-23

Abstract excerpt

It remains unclear whether podocyte loss directly causes acute renal tubular cell (RTC) damage and interstitial fibrosis, thereby leading to renal failure. Here, we applied intermedilysin (ILY)-mediated human CD59 (hCD59) cell ablation to generate an acute, specific podocyte-ablation mouse model. Cre-induced hCD59 transgenics (ihCD59) were crossed with Nphs2Cre to generate ihCD59 +/- /Nphs2Cre +/- mice. The sp...

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Literature Corpus work: 7293900b-b27f-55dd-a5fd-ec8d3a93988a
DOI: 10.64898/2026.03.19.712955

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