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Glioportal: a comprehensive transcriptomic resource unveiling ligand-mediated mesenchymal transition in glioblastoma

15 Jun 2025

Abstract excerpt

BACKGROUND: Multi-omics profiling of glioblastoma (GBM) has unraveled two aspects fundamental to its aggressiveness and lethality that is molecular heterogeneity inherent to the tumor and cellular plasticity modulated by the microenvironment. Yet, empirical validation to identify causal factors for these complex mechanisms is rather scarce. Here, we report our endeavor in establishing Glioportal, a GBM tumor...

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PMID: 40518441
DOI: 10.1093/neuonc/noaf145

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