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Article

Targeting TWIST 1 through loss of function inhibits tumorigenicity of human glioblastoma

13 May 2018

Abstract excerpt

TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial-to-mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self-renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of TW has not been established through loss-of-function studies in human GBM cell xenograft models. The effects of TW loss of function (gene editing and...

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PMID: 29754406
DOI: 10.1002/1878-0261.12320

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