Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma.

Journal of experimental & clinical cancer research : CR - 4 Sept 2024

Wang Hao, Yao Lin, Chen Jinming, Li Yanyan, Su Zuopeng, Liu Yongsheng, Li Wen, Xiong Yun, Gao Heyang, Zhang Xiao, Zhou Youxin

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is an immunosuppressive, universally lethal cancer driven by glioblastoma stem cells (GSCs). The interplay between GSCs and immunosuppressive microglia plays crucial roles in promoting the malignant growth of GBM; however, the molecular mechanisms underlying this crosstalk are unclear. This study aimed to investigate the role of POSTN in maintaining GSCs and the immunosuppressive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Cell Proliferation

Share to Glioblastoma

Share to Microglia

Share to Neoplastic Stem Cells

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 39227950
DOI: 10.1186/s13046-024-03175-9
PMCID: PMC11373117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma.PMID 39227950Read ↗

Cancer Stem Cells and Immunosuppressive Microenvironment in GliomaSemantic proximity Read ↗

Molecular Heterogeneity and Immunosuppressive Microenvironment in GlioblastomaSemantic proximity Read ↗

Circadian Regulator CLOCK Drives Immunosuppression in GlioblastomaSemantic proximity Read ↗

Progenitor Cells, Microglia, and Non-coding RNAs: Orchestrators of Glioblastoma Pathogenesis and Therapeutic ResistanceSemantic proximity Read ↗

SMAC mimetic drives microglia phenotype and glioblastoma immune microenvironment.Semantic proximity Read ↗

Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated MacrophagesSemantic proximity Read ↗

Astrocyte immunosuppressive activity in glioblastoma depends on ZEB1 and is counteracted by CXCL14Semantic proximity Read ↗

Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor MicroenvironmentSemantic proximity Read ↗

Single-cell profiling and zebrafish avatars reveal <i>LGALS1</i> as immunomodulating target in glioblastomaSemantic proximity Read ↗

Phenotypic plasticity of myeloid cells in glioblastoma development, progression, and therapeutics.Semantic proximity Read ↗

EGFL7 promotes immune evasion in glioblastoma by interaction with integrin β <sub>2</sub>Semantic proximity Read ↗

The Dynamics of Interactions Among Immune and Glioblastoma Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.