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Glioblastoma multiforme: insights into pathogenesis, key signaling pathways, and therapeutic strategies

26 Feb 2025

Abstract excerpt

Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by a poor prognosis and significant resistance to existing treatments. Despite progress in therapeutic strategies, the median overall survival remains approximately 15 months. A hallmark of GBM is its intricate molecular profile, driven by disruptions in multiple signaling pathways, including...

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PMID: 40011944
DOI: 10.1186/s12943-025-02267-0

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