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Article

Enrichment of G-to-U Substitution in SARS-CoV-2 Functional Regions and Its Compensation via Concurrent Mutations.

Journal of medical virology - 1 Apr 2025

Sulaiman Xierzhatijiang, Han Yan, Liu Sheng, Li Kailing, Shang Marissa, Yang Lei, White Kenneth, Zang Yong, Shen Jikui, Wan Jun

Abstract excerpt

We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS-CoV-2 genomes. Among 10 012 SNVs, APOBEC-mediated C-to-U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing-related substitutions including (A > G, U > C, G > A). However, C > U mutations were less frequent in functional regions, for example, S protein, intrinsic disordered regions, and nonsynonymous...

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Topics

SARS-CoV-2
Humans
COVID-19
Mutation
Genome, Viral
Spike Glycoprotein, Coronavirus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

RNA Editing

Source

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Identifiers

PMID: 40249051
DOI: 10.1002/jmv.70353
PMCID: PMC12007394

Provenance

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