Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rampant C-to-U deamination accounts for the intrinsically high mutation rate in SARS-CoV-2 spike gene.

RNA (New York, N.Y.) - 1 Jul 2022

Liu Xueyan, Liu Xuan, Zhou Jie, Dong Yu, Jiang Wen, Jiang Wenqing

Abstract excerpt

The high mutation rate of SARS-CoV-2 largely complicates our control of the pandemic. In particular, it is currently unclear why the spike (S) gene has an extraordinarily high mutation rate among all SARS-CoV-2 genes. By analyzing the occurrence of fixed synonymous mutations between SARS-CoV-2 and RaTG13, and profiling the DAF (derived allele frequency) of polymorphic synonymous sites among millions of worldwide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to Deamination
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation Rate

Share to Pandemics

Share to RNA Interference and Gene Delivery

Share to RNA regulation and disease

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 35508354
DOI: 10.1261/rna.079160.122
PMCID: PMC9202584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rampant C-to-U deamination accounts for the intrinsically high mutation rate in SARS-CoV-2 spike gene.PMID 35508354Read ↗

Mutation profile of over 4500 SARS-CoV-2 isolations reveals prevalent cytosine-to-uridine deamination on viral RNAs.Semantic proximity Read ↗

Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories.Semantic proximity Read ↗

Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution.Semantic proximity Read ↗

Rampant C->U hypermutation in the genomes of SARS-CoV-2 and other coronaviruses – causes and consequences for their short and long evolutionary trajectoriesSemantic proximity Read ↗

Identification of a High-frequency Intra-host SARS-CoV-2 spike Variant with Enhanced Cytopathic and Fusogenic EffectSemantic proximity Read ↗

C→U transition biases in SARS-CoV-2: still rampant 4 years from the start of the COVID-19 pandemicSemantic proximity Read ↗

SNPs or RNA modifications? Concerns on mutation-based evolutionary studies of SARS-CoV-2.Semantic proximity Read ↗

Mutational Asymmetries in the SARS-CoV-2 Genome May Lead to Increased Hydrophobicity of Virus Proteins.Semantic proximity Read ↗

Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responsesSemantic proximity Read ↗

Mutation Patterns of Human SARS-CoV-2 and Bat RaTG13 Coronavirus Genomes Are Strongly Biased Towards C>U Transitions, Indicating Rapid Evolution in Their Hosts.Semantic proximity Read ↗

The continuing discovery on the evidence for RNA editing in SARS-CoV-2.Semantic proximity Read ↗

Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.