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Characterization of SARS-CoV-2 Mutational Signatures from 1.5+ Million Raw Sequencing Samples.

Viruses - 20 Dec 2022

Aroldi Andrea, Angaroni Fabrizio, D'Aliberti Deborah, Spinelli Silvia, Crespiatico Ilaria, Crippa Valentina, Piazza Rocco, Graudenzi Alex, Ramazzotti Daniele

Abstract excerpt

We present a large-scale analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) substitutions, considering 1,585,456 high-quality raw sequencing samples, aimed at investigating the existence and quantifying the effect of mutational processes causing mutations in SARS-CoV-2 genomes when interacting with the human host. As a result, we confirmed the presence of three well-differentiated mutational...

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PMID: 36680048
DOI: 10.3390/v15010007
PMCID: PMC9864147

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