Mutational Asymmetries in the SARS-CoV-2 Genome May Lead to Increased Hydrophobicity of Virus Proteins.

doi:10.3390/genes12060826

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Mutational Asymmetries in the SARS-CoV-2 Genome May Lead to Increased Hydrophobicity of Virus Proteins.

Genes - 27 May 2021

Matyášek Roman, Řehůřková Kateřina, Berta Marošiová Kristýna, Kovařík Aleš

Abstract excerpt

The genomic diversity of SARS-CoV-2 has been a focus during the ongoing COVID-19 pandemic. Here, we analyzed the distribution and character of emerging mutations in a data set comprising more than 95,000 virus genomes covering eight major SARS-CoV-2 lineages in the GISAID database, including genotypes arising during COVID-19 therapy. Globally, the C>U transitions and G>U transversions were the most represented...

Topics

APOBEC Deaminases
Alleles
Amino Acid Substitution
Amino Acids
COVID-19
Evolution, Molecular
Genetic Variation
Genome, Viral
Genotype
Host-Pathogen Interactions
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrophobic and Hydrophilic Interactions

Mutation

Phylogeny

Polymorphism, Single Nucleotide

Protein Binding

Protein Interaction Domains and Motifs

SARS-CoV-2

Source

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Identifiers

PMID: 34072181
DOI: 10.3390/genes12060826
PMCID: PMC8227412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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