Article

The Roles of APOBEC-mediated RNA Editing in SARS-CoV-2 Mutations, Replication and Fitness

2021-12-21

Abstract excerpt

<h4>ABSTRACT</h4> During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by RNA-polymerases and modification by host factors. Analysis of SARS-CoV-2 sequence from patients showed a strong bias toward C-to-U mutation, suggesting a potential mutational role by host APOBEC cytosine deaminases that posses...

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Literature Corpus work: 3deb471b-bd2b-5afd-af20-944ac89d9a95
DOI: 10.1101/2021.12.18.473309

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