Assessing the causal association between age at menarche and genetic susceptibility to future gastroesophageal reflux disease risks: A two-sample Mendelian randomization study.

Abstract excerpt

OBJECTIVE: Evidence indicates that menarche onset is associated with various health outcomes. Gastroesophageal reflux disease (GERD) is a prevalent condition, which may be influenced by the age at menarche (AAM). The study aims to investigate the potential causal relationship between the AAM and GERD. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis utilizing single nucleotide...

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