Mendelian randomization identifies age at menarche as an independent causal effect factor for gestational diabetes mellitus

Abstract excerpt

AIMS: The relationship between age at menarche (AAM) and gestational diabetes mellitus (GDM) risk is still inconclusive. This Mendelian randomization (MR) analysis was used to assess systematically the causal relationship between AAM and GDM risk in human beings. MATERIALS AND METHODS: Single-nucleotide polymorphisms associated with AAM, oestradiol levels, sex hormone-binding globulin (SHBG) levels and...

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