Genetic association and potential mediators between age at menarche and cholelithiasis: a two-sample two-step bidirectional mendelian randomization study.

Abstract excerpt

OBJECTIVE: Pubertal reproductive factors, such as age at menarche, have been linked to various long-term health outcomes, but their potential role in the development of cholelithiasis remains insufficiently studied. Although observational studies have suggested a possible association between menarche timing and gallstone risk, inconsistent findings and methodological limitations have left this relationship...

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