Article
IFITM3 affects the level of antibody response after influenza vaccination.
Emerging microbes & infections - 1 Dec 2020
Lei Na, Li Yan, Sun Qiang, Lu Jian, Zhou Jianfang, Li Zi, Liu Liqi, Guo Junfeng, Qin Kun, Wang Haibin, Zhao Jianhong, Li Chong, Sun Lingli, Wang Dayan, Zhao Zhendong, Shu Yuelong
Abstract excerpt
Interferon-induced transmembrane protein 3 (IFITM3) as an antiviral factor can inhibit replication of several viruses including influenza virus. A single-nucleotide polymorphism rs12252-C of IFITM3 results in a truncated IFITM3 protein lacking its first 21 amino acids, which is much higher in the Han Chinese population and associated with severe illness in adults infected with pandemic influenza H1N1/09 virus. To...
Topics
- Adaptive Immunity
- Adolescent
- Adult
- Animals
- Antibodies, Viral
- Antibody Formation
- Asian People
- Female