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Article

Cholinergic Degeneration and Cognitive Function in Early GBA1-Related Parkinson's Disease.

Annals of neurology - 1 Aug 2025

Slingerland Sofie, van der Zee Sygrid, Carli Giulia, Slomp Anne C, d'Angremont Emile, Boertien Jeffrey M, van Laar Teus

Abstract excerpt

OBJECTIVE: The phenotype of patients with Parkinson's disease carrying GBA1 variants (GBA-PD) suggest similarities to symptomatology associated with early cholinergic system degeneration. Therefore, this study aims to investigate the clinical features and the cholinergic innervation pattern in patients with early GBA-PD versus those without the GBA1 mutation (non-GBA-PD). METHODS: A total of 46 GBA-PD and 104...

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Source

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Identifiers

PMID: 40237446
DOI: 10.1002/ana.27248
PMCID: PMC12278189

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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