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Article

Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease.

PloS one - 1 Jan 2017

Huertas Ismael, Jesús Silvia, García-Gómez Francisco Javier, Lojo José Antonio, Bernal-Bernal Inmaculada, Bonilla-Toribio Marta, Martín-Rodriguez Juan Francisco, García-Solís David, Gómez-Garre Pilar, Mir Pablo

Abstract excerpt

The dual syndrome hypothesis for cognitive impairment in Parkinson's disease (PD) establishes a dichotomy between a frontrostriatal dopamine-mediated syndrome, which leads to executive deficits, and a posterior cortical syndrome, which leads to dementia. Certain genes have been linked to these syndromes although the exact contribution is still controversial. The study's objective was to investigate the role of...

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Identifiers

PMID: 28399184
DOI: 10.1371/journal.pone.0175560
PMCID: PMC5388496

Genes

COMT
SNCA
MAPT
APOE
CIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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