Article

Male sex accelerates cognitive decline in GBA1 Parkinson’s Disease

2024-10-17

Abstract excerpt

<title>Abstract</title> <p>We evaluated 128 GBA and 432 nonGBA Parkinson’s disease (PD) subjects. Baseline clinical features and dopaminergic activity were assessed, together with 7-year clinical follow-up. Survival analyses assessed the independent and interactive effects of male sex and GBA1 mutations on cognitive impairment. At baseline, GBA-PD males showed greater motor impairment, sleep disorders and memory...

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Literature Corpus work: 51e0d9c1-abe4-5104-8299-2e62871ab36c
DOI: 10.21203/rs.3.rs-4885538/v1

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