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Article

Clinical and Dopamine Transporter Imaging Trajectories in a Cohort of Parkinson's Disease Patients with GBA Mutations.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2022

Caminiti Silvia Paola, Carli Giulia, Avenali Micol, Blandini Fabio, Perani Daniela

Abstract excerpt

BACKGROUND: Glucosylceramidase (GBA) mutations are considered the most common genetic risk factors for developing Parkinson's disease (PD). OBJECTIVES: We aimed to assess, at different time points, the integrity of brain striatal and extra-striatal dopamine pathways and clinical phenotype of a group of PD subjects bearing heterozygous GBA mutations (GBA-PD), compared with a group of idiopathic PD patients (iPD)...

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Identifiers

PMID: 34596920
DOI: 10.1002/mds.28818

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