Article

Cholinergic innervation topography in GBA-associated<i>de novo</i>Parkinson’s disease patients

2023-06-20

Abstract excerpt

The most common genetic risk factors for Parkinson’s disease are GBA1 mutations, encoding the lysosomal enzyme glucocerebrosidase. Patients with GBA1 mutations (GBA-PD) exhibit earlier age of onset and faster disease progression with more severe cognitive impairments, postural instability, and gait problems. The GBA-PD features suggests more severe cholinergic system pathologies. PET imaging with the vesicular ace...

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Literature Corpus work: 61e31638-3b98-5906-b774-e6872d246662
DOI: 10.1101/2023.06.16.23290981

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