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Article

A multicenter longitudinal study of cholinergic subgroups in Parkinson disease

1 Jul 2025

Abstract excerpt

Abstract Parkinson disease (PD) is a heterogeneous syndrome. There is a need for biology-driven subtyping to inform specific therapeutic strategies. In a two-center study with de novo and established PD cohorts, we use vesicular acetylcholine transporter ligand [18F]FEOBV brain PET to assess cholinergic systems changes in early to moderate PD. Principal component analysis (PCA) is applied to data from 245 PD...

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PMID: 40593607
DOI: 10.1038/s41467-025-60815-0

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