Article
Precision proteogenomics reveals pan-cancer impact of germline variants.
Cell - 1 May 2025
Martins Rodrigues Fernanda, Terekhanova Nadezhda V, Imbach Kathleen J, Clauser Karl R, Esai Selvan Myvizhi, Mendizabal Isabel, Geffen Yifat, Akiyama Yo, Maynard Myranda, Yaron Tomer M, Li Yize, Cao Song, Storrs Erik P, Gonda Olivia S, Gaite-Reguero Adrian, Govindan Akshay, Kawaler Emily A, Wyczalkowski Matthew A, Klein Robert J, Turhan Berk, Krug Karsten, Mani D R, Leprevost Felipe da Veiga, Nesvizhskii Alexey I, Carr Steven A, Fenyö David, Gillette Michael A, Colaprico Antonio, Iavarone Antonio, Robles Ana I, Huang Kuan-Lin, Kumar-Sinha Chandan, Aguet François, Lazar Alexander J, Cantley Lewis C, Marigorta Urko M, Gümüş Zeynep H, Bailey Matthew H, Getz Gad, Porta-Pardo Eduard, Ding Li
Abstract excerpt
We investigate the impact of germline variants on cancer patients' proteomes, encompassing 1,064 individuals across 10 cancer types. We introduced an approach, "precision peptidomics," mapping 337,469 coding germline variants onto peptides from patients' mass spectrometry data, revealing their potential impact on post-translational modifications, protein stability, allele-specific expression, and protein...
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