Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.

Genome medicine - 18 Jul 2017

Alfaro Javier A, Ignatchenko Alexandr, Ignatchenko Vladimir, Sinha Ankit, Boutros Paul C, Kislinger Thomas

Abstract excerpt

BACKGROUND: Onco-proteogenomics aims to understand how changes in a cancer's genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from mass-spectrometry (MS) datasets, as traditional proteomic analyses only identify proteins from a reference sequence database. METHODS: We established proteomic workflows to detect peptide variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Cell Line, Tumor
Share to Mass Spectrometry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasm Proteins

Share to Polymorphism, Genetic

Share to Protein Isoforms

Share to Proteomics

Share to Workflow

Source

Open in PubMed Open full text

Identifiers

PMID: 28716134
DOI: 10.1186/s13073-017-0454-9
PMCID: PMC5514513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.PMID 28716134Read ↗

XMAn Update - A Database of Homo sapiens Mutated PeptidesSemantic proximity Read ↗

Proteogenomic Analysis of Protein Sequence Alterations in Breast Cancer CellsSemantic proximity Read ↗

Enabling Variant Proteogenomic Assay Development Through a Peptide Target Selection Pipeline and Web Application.Semantic proximity Read ↗

A bioinformatics workflow for variant peptide detection in shotgun proteomics.Semantic proximity Read ↗

XMAn: a Homo sapiens mutated-peptide database for the MS analysis of cancerous cell states.Semantic proximity Read ↗

Proteogenomic Analysis of Single Amino Acid Polymorphisms in Cancer Research.Semantic proximity Read ↗

Exome-driven characterization of the cancer cell lines at the proteome level: the NCI-60 case study.Semantic proximity Read ↗

Variant peptide detection utilizing mass spectrometry: laying the foundations for proteogenomic identification and validation.Semantic proximity Read ↗

CMPD: cancer mutant proteome database.Semantic proximity Read ↗

An Analysis of the Sensitivity of Proteogenomic Mapping of Somatic Mutations and Novel Splicing Events in Cancer.Semantic proximity Read ↗

CusVarDB: A tool for building customized sample-specific variant protein database from next-generation sequencing datasetsSemantic proximity Read ↗

Global impact of germline structural variation on the cancer proteome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.