Enabling Variant Proteogenomic Assay Development Through a Peptide Target Selection Pipeline and Web Application.

Abstract excerpt

The quantification of key protein variants can guide precision oncology to enable better identification of driver mutations. Bottom-up assays infer parent protein levels through the quantification of surrogate peptides. Assay methods designed for absolute quantification of protein variants, such as multiple reaction monitoring mass spectrometry (MRM-MS), can achieve quantitation with high precision and...

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