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Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity

10 Apr 2025

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a cell state transition co-opted by cancer that drives metastasis via stable intermediate states. Here we study EMT dynamics to identify marker genes of highly metastatic intermediate cells via mathematical modeling with single-cell RNA sequencing (scRNA-seq) data. Across multiple tumor types and stimuli, we identified genes consistently upregulated in EMT intermediate...

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PMID: 40210876
DOI: 10.1038/s41540-025-00512-2

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