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Article

Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing

3 May 2021

Abstract excerpt

The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal development and in cancer progression. EMT is induced by various signaling pathways, including TGF-β, BMP, Wnt-β-catenin, NOTCH, Shh, and receptor tyrosine kinases. In this study, we performed single-cell RNA sequencing on MCF10A cells undergoing EMT by TGF-β1 stimulation. Our comprehensive analysis revealed that cells progress...

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PMID: 33941680
DOI: 10.1073/pnas.2102050118

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