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Article

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution.

Nature communications - 6 Dec 2019

Karacosta Loukia G, Anchang Benedict, Ignatiadis Nikolaos, Kimmey Samuel C, Benson Jalen A, Shrager Joseph B, Tibshirani Robert, Bendall Sean C, Plevritis Sylvia K

Abstract excerpt

Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on cancer progression and drug resistance. Using mass cytometry time-course analysis, we resolve lung cancer EMT states through TGFβ-treatment and identify, through TGFβ-withdrawal, a distinct MET state. We demonstrate significant differences between EMT and...

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Source

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Identifiers

PMID: 31811131
DOI: 10.1038/s41467-019-13441-6
PMCID: PMC6898514

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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