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Article

Exploring molecular mechanisms of aminoglycoside resistance in Escherichia coli MG1655 using the antibiotic resistance growth plate.

Scientific reports - 4 Mar 2026

Cullen L B L, Eldridge C J L, Jones B P, Forster-Wilkins G, Lawton S P, Fielder M D

Abstract excerpt

The overuse of antibiotics in human and animal health has driven the rapid emergence of multi-drug-resistant bacterial strains. To investigate the molecular mechanisms underlying resistance, we developed the Antibiotic Resistance Growth Plate (ARGP), an experimental evolution tool that imposes a spatiotemporal antibiotic gradient. Using the ARGP, Escherichia coli MG1655 populations developed resistance to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41781441
DOI: 10.1038/s41598-026-41386-6
PMCID: PMC13068909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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