Article
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance.
Science translational medicine - 8 Jan 2025
Martins Ana, Judák Fanni, Farkas Zoltán, Szili Petra, Grézal Gábor, Csörgő Bálint, Czikkely Márton Simon, Maharramov Elvin, Daruka Lejla, Spohn Réka, Balogh Dávid, Daraba Andreea, Juhász Szilvia, Vágvölgyi Máté, Hunyadi Attila, Cao Yihui, Sun Zhenquan, Li Xuechen, Papp Balázs, Pál Csaba
Abstract excerpt
Several antibiotic candidates are in development against Gram-positive bacterial pathogens, but their long-term utility is unclear. To investigate this issue, we studied the laboratory evolution of resistance to antibiotics that have not yet reached the market. We found that, with the exception of compound SCH79797, antibiotic resistance generally readily evolves in Staphylococcus aureus. Cross-resistance was...
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