Points to consider regarding prophylactic total gastrectomy in germline CDH1 variant carriers.

Abstract excerpt

Pathogenic germline CDH1 mutation confers high risk for developing diffuse gastric and lobular breast cancers in asymptomatic carriers. In these individuals, the estimated gastric cancer risk at 80 years of age is up to 70% for males and 56% for females. Due to this high-risk predisposition, prophylactic total gastrectomy is considered a unique life-saving approach in germline CDH1 carriers, as endoscopy often...

Topics

• Female
• Humans
• Antigens, CD
• Cadherins
• Gastrectomy
• Genetic Predisposition to Disease
• Germ-Line Mutation
• Prophylactic Surgical Procedures
• Stomach Neoplasms
• Male