Predicting reverse-bound peptide conformations in MHC Class II with PANDORA.

Abstract excerpt

Recent discoveries have transformed our understanding of peptide binding in Major Histocompatibility Complex (MHC) molecules, showing that peptides, for some MHC class II alleles, can bind in a reverse orientation (C-terminus to N-terminus) and can still effectively activate CD4+ T cells. These finding challenges established concepts of immune recognition and suggests new pathways for therapeutic intervention,...

Topics

• Histocompatibility Antigens Class II
• Peptides
• Humans
• Protein Binding
• Protein Conformation
• Algorithms