Article

Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA0201

2024-11-21

Abstract excerpt

Class 1 major histocompatibility complexes (MHC-I), encoded by the highly polymorphic HLA-A, HLA-B, and HLA-C genes in humans, are expressed on all nucleated cells. Both self and foreign proteins are processed to peptides of 8 to 10 amino acids, loaded into MCH-1 within the endoplasmic reticulum and then presented on the cell surface. Foreign peptides presented in this fashion activate CD8+ T cells and their immun...

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Literature Corpus work: 45c039c9-0db0-5b1b-8754-9251bf4d149f
DOI: 10.1101/2024.11.19.624425

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