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Article

Increased SUMO-activating enzyme subunit 1 promotes glycolysis and fibrotic phenotype of diabetic nephropathy.

Biochemical pharmacology - 1 Jul 2025

Wusiman Reziwanguli, Haimiti Shayila, Abuduaini Hanikezi, Yang Miaoyan, Wang Yitian, Gu Meijun, Sailike Ali, Gao Lei

Abstract excerpt

Renal fibrosis is a prominent feature of diabetic nephropathy (DN), and the connection between renal fibrosis and abnormal glycolysis is not fully understood. SUMO-activating enzyme subunit 1 (SAE1) plays a crucial role in the SUMO modification process and is related to abnormal glycolysis. Despite this, the specific role of SAE1 in DN and its mechanism are not well defined. To investigate this, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40194606
DOI: 10.1016/j.bcp.2025.116920

Genes

SAE1
PFKFB3
HK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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